- small molecule tyrosine kinase inhibitors
- Медицина: низкомолекулярные ингибиторы тирозинкиназы
Универсальный англо-русский словарь. Академик.ру. 2011.
small molecule tyrosine kinase inhibitors
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Discovery and development of small molecule c-Met inhibitors — The c Met (mesenchymal epithelial transition) tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and angiogenesis.[1] c Met is a receptor tyrosine kinase,[2] which can cause a wide variety of different cancers, such… … Wikipedia
Bcr-Abl tyrosine-kinase inhibitor — Bcr Abl tyrosine kinase inhibitors (TKI) are the first line therapy for most patients with chronic myelogenous leukemia (CML). In more than 90% cases CML is caused by chromosomal abnormality resulting in the formation of a so called Philadelphia… … Wikipedia
Protein kinase — A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation). This class of protein may further be separated into subsets as in the case of protein kinase C PKC alpha, PKC beta,… … Wikipedia
Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors — (NRTIs and NtRTIs) began in the 1980s when the AIDS epidemic hit Western societies. NRTIs inhibit the reverse transcriptase (RT), an enzyme that controls the replication of the genetic material of the human immunodeficiency virus (HIV). The first … Wikipedia
Discovery and development of proton pump inhibitors — Proton pump inhibitors (PPIs) block the gastric Hydrogen potassium ATPase (H+,K+ ATPase) and inhibit gastric acid secretion. These drugs have emerged as the treatment of choice for acid related diseases, including gastroesophageal reflux disease… … Wikipedia
Discovery and development of cyclooxygenase 2 inhibitors — Cyclooxygenases are enzymes that take part in a complex biosynthetic cascade that results in the conversion of polyunsaturated fatty acids to prostaglandins and thromboxane(s).[1] Their main role is to catalyze the transformation of arachidonic… … Wikipedia
Discovery and development of non-nucleoside reverse-transcriptase inhibitors — Non nucleoside reverse transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). NNRTIs inhibit reverse transcriptase (RT), an enzyme that controls the replication of the genetic… … Wikipedia
Lapatinib — NOTOC drugbox IUPAC name = N [3 chloro 4 [(3 fluorophenyl)methoxy] phenyl] 6 [5 [(2 methylsulfonylethylamino)methyl] 2 furyl] quinazolin 4 amine |3D structure of the Lapatinib molecule CAS number = 388082 78 8 ATC prefix = L01 ATC suffix = XE07… … Wikipedia
Joseph Schlessinger — Joseph Schlessinger, Ph.D. is Chair of the Pharmacology Department at Yale University School of Medicine in New Haven, Connecticut. His area of research is signaling through tyrosine phosphorylation which is important in many areas of cellular… … Wikipedia
c-Met — Met proto oncogene (hepatocyte growth factor receptor) Crystallographic structure of MET. PDB rendering based on 1r0p … Wikipedia
Erlotinib — Systematic (IUPAC) name … Wikipedia
